KDELR1
Domain
Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (PubMed:30846601).
Function
Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
Post-translational modifications
Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function.
Sequence Similarities
Belongs to the ERD2 family.
Cellular localization
- Golgi apparatus membrane
- Multi-pass membrane protein
- Cytoplasmic vesicle
- COPI-coated vesicle membrane
- Multi-pass membrane protein
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Endoplasmic reticulum-Golgi intermediate compartment membrane
- Multi-pass membrane protein
- Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.
Alternative names
ERD2.1, KDELR1, ER lumen protein-retaining receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, Putative MAPK-activating protein PM23, KDEL receptor 1