KDM2B

Domain

The LRR repeats are required for the interaction with the PCGF1-BCORL1 heterodimeric complex.

The JmjC domain mediates demethylation activity (PubMed:17994099). It is also required for repression of ribosomal RNA genes (PubMed:17994099).

The CXXC zinc finger mediates binding to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides.

The F-box domain mediates interaction with UBB.

Function

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).

Sequence similarities

Belongs to the JHDM1 histone demethylase family.

Cellular localization

• Nucleus
• Nucleolus
• Nucleus
• Chromosome

Alternative names

• Lysine-specific demethylase 2B
• CXXC-type zinc finger protein 2
• F-box and leucine-rich repeat protein 10
• F-box protein FBL10
• F-box/LRR-repeat protein 10
• JmjC domain-containing histone demethylation protein 1B
• Jumonji domain-containing EMSY-interactor methyltransferase motif protein
• Protein-containing CXXC domain 2
• [Histone-H3]-lysine-36 demethylase 1B
• Protein JEMMA
• KDM2B
• CXXC2
• FBL10
• FBXL10
• JHDM1B
• NDY1
• PCCX2

Database links

• entrezGene:84678
• omim:609078
• swissprot:Q8NHM5

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

152615Da