Kdm4b
Developmental stage
Expression is especially strong in the hippocampus and throughout the CNS from embryonic periods through adulthood.
Domain
The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity).
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). Plays a critical role in the development of the central nervous system (CNS).
Sequence Similarities
Belongs to the JHDM3 histone demethylase family.
Cellular localization
- Nucleus
Alternative names
Jhdm3b, Jmjd2b, Kdm4b, Lysine-specific demethylase 4B, JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B, [histone H3]-trimethyl-L-lysine(9) demethylase 4B