Skip to main content

KDM4D / JMJD2D

Function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Sequence similarities

Belongs to the JHDM3 histone demethylase family.

Cellular localization

  • Nucleus

Alternative names

  • Lysine-specific demethylase 4D
  • JmjC domain-containing histone demethylation protein 3D
  • Jumonji domain-containing protein 2D
  • [histone H3]-trimethyl-L-lysine(9) demethylase 4D
  • JMJD2D
  • KDM4D
  • JHDM3D

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

58603Da