KDM5D / Jarid1D / SMCY

The JmjC domain is required for enzymatic activity.

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.

Belongs to the JARID1 histone demethylase family.

Expression is highly down-regulated in metastatic prostate tumors.

• Nucleus

HY, HYA, JARID1D, KIAA0234, SMCY, KDM5D, Lysine-specific demethylase 5D, Histocompatibility Y antigen, Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY, [histone H3]-trimethyl-L-lysine(4) demethylase 5D, H-Y

• entrezGene:8284
• omim:426000
• swissprot:Q9BY66

Proteins

Epigenetics

174073Da