KEL
Function
Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the peptidase M13 family.
Tissue Specificity
Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythroid tissues, including brain, spleen, lymph nodes and bone marrow.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
- Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
Alternative names
CD238, Kell blood group glycoprotein, KEL