kgp
Function
Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria.
Post-translational modifications
Proteolytically cleaved into a catalytic subunit and three adhesins. Arg-gingipain is involved in this post-translational processing (By similarity).
Sequence Similarities
Belongs to the peptidase C25 family.
Cellular localization
- Lys-gingipain catalytic subunit
- Secreted
Alternative names
PGN_1728, kgp, Lys-gingipain, Lysine-specific cysteine proteinase Kgp