KIAA0907

The C-terminal part is necessary for the interaction with the PRP19C/Prp19 complex/NTC/Nineteen complex.

The KH domains mediate RNA-binding.

RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703).

Belongs to the KHDC4 family.

Ubiquitous. Expressed at high level in skeletal muscle, kidney, heart, brain and liver.

• Nucleus
• Cytoplasm

BLOM7, KIAA0907, SNORA80EHG, KHDC4, KH homology domain-containing protein 4, Brings lots of money 7, Pre-mRNA splicing factor protein KHDC4

• entrezGene:22889
• swissprot:Q7Z7F0

Proteins

64845Da