KIF13B
Function
Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.
Post-translational modifications
Phosphorylated at Ser-1381 and Ser-1410 by MARK2, promoting interaction with 14-3-3 and inhibiting microtubule-dependent accumulation and formation of axons.
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell projection
- Axon
- accumulates at the distal part of the microtubules in the tips of axons, but not of dendrites.
Alternative names
GAKIN, KIAA0639, KIF13B, Kinesin-like protein KIF13B, Kinesin-like protein GAKIN