KIF20A
Function
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
Involvement in disease
Cardiomyopathy, familial restrictive 6
RCM6
A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. RCM6 is an autosomal recessive, severe form characterized by prenatal onset, irreversible heart failure and early death.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Cellular localization
- Golgi apparatus
- Cytoplasm
- Cytoskeleton
- Spindle
- Localizes to the spindle midzone during anaphase and telophase.
Alternative names
MKLP2, RAB6KIFL, KIF20A, Kinesin-like protein KIF20A, GG10_2, Mitotic kinesin-like protein 2, Rab6-interacting kinesin-like protein, Rabkinesin-6, MKlp2