KIF23
Function
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
Involvement in disease
Anemia, congenital dyserythropoietic, 3A
CDAN3A
An autosomal dominant blood disorder characterized by ineffective erythropoiesis, hemolytic anemia, macrocytosis in the peripheral blood, intravascular hemolysis, and giant multinucleated erythroblasts in the bone marrow.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Ubiquitinated. Deubiquitinated by USP8/UBPY.
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Tissue Specificity
Widely expressed.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoskeleton
- Spindle
- Midbody
- Midbody ring
- Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
Alternative names
KNSL5, MKLP1, KIF23, Kinesin-like protein KIF23, Kinesin-like protein 5, Mitotic kinesin-like protein 1