KIF26A
Developmental stage
Expressed in the cortical plate, subplate, and intermediate zone of the mid-gestation fetal cortex.
Function
Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617).
Involvement in disease
Cortical dysplasia, complex, with other brain malformations 11
CDCBM11
An autosomal recessive disorder of aberrant neuronal migration during brain development. CDCBM11 is characterized by dilated ventricles and reduced white matter, and is associated with axonal developmental defects.
None
The disease may be caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
Tissue Specificity
In the developing cerebral cortex, preferentially expressed by migrating excitatory neurons.
Cellular localization
- Cytoplasm
- Cytoskeleton
Alternative names
KIAA1236, KIF26A, Kinesin-like protein KIF26A