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KIFAP3

Function

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity).

Post-translational modifications

Phosphorylated on tyrosine residues by SRC in vitro; this reduces the binding affinity of the protein for RAP1GDS1.

Alternative names

KIF3AP, SMAP, KIFAP3, Kinesin-associated protein 3, KAP-3, KAP3, Smg GDS-associated protein

swissprot:Q92845 entrezGene:22920 omim:601836