KIR3DL2

Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270). Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).

Belongs to the immunoglobulin superfamily.

Expressed in astrocytes.

• Cell membrane
• Single-pass type I membrane protein

CD158k, CD158K, NKAT4, KIR3DL2, Killer cell immunoglobulin-like receptor 3DL2, CD158 antigen-like family member K, Natural killer-associated transcript 4, p70 natural killer cell receptor clone CL-5, NKAT-4, p70 NK receptor CL-5

• entrezGene:3812
• omim:604947
• swissprot:P43630

Proteins

Immunology & Infectious Disease

50230Da