KIR3DL2
Function
Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270). Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).
Sequence Similarities
Belongs to the immunoglobulin superfamily.
Tissue Specificity
Expressed in astrocytes.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD158k, CD158K, NKAT4, KIR3DL2, Killer cell immunoglobulin-like receptor 3DL2, CD158 antigen-like family member K, Natural killer-associated transcript 4, p70 natural killer cell receptor clone CL-5, NKAT-4, p70 NK receptor CL-5