Kirrel1
Function
Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:11416156). Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Post-translational modifications
Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding (By similarity).
N-glycosylated.
Sequence Similarities
Belongs to the immunoglobulin superfamily.
Tissue Specificity
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Predominantly located at podocyte slit diaphragm.
Alternative names
Kirrel, Neph1, Kirrel1, Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Nephrin-like protein 1