KIRREL2
Function
May regulate basal insulin secretion.
Post-translational modifications
N-glycosylated.
The extracellular domain is cleaved leading to the generation of a soluble fragment and a membrane-bound C-terminal fragment, which is further cleaved by gamma-secretase.
Sequence Similarities
Belongs to the immunoglobulin superfamily.
Tissue Specificity
Highly expressed in beta-cells of the pancreatic islets.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin.
Alternative names
NEPH3, UNQ5827/PRO19646, KIRREL2, Kin of IRRE-like protein 2, Kin of irregular chiasm-like protein 2, Nephrin-like protein 3