Kitlg
Developmental stage
Acts in the early stages of hematopoiesis.
Function
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Post-translational modifications
A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.
The identity of N- and O-linked saccharides is not reported in PubMed:1708771. The O-linked polysaccharides are probably the mucin type linked to GalNAc.
Sequence Similarities
Belongs to the SCF family.
Cellular localization
- Isoform 1
- Cell membrane
- Single-pass type I membrane protein
- Isoform 2
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Cell membrane
- Single-pass type I membrane protein
- Cell projection
- Lamellipodium
- Cell projection
- Filopodium
- Soluble KIT ligand
- Secreted
Alternative names
Kitl, Mgf, Kitlg, Kit ligand, Hematopoietic growth factor KL, Mast cell growth factor, Stem cell factor, c-Kit ligand, MGF, SCF