KLF17
Function
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).
Sequence Similarities
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Cellular localization
- Nucleus
Alternative names
ZNF393, KLF17, Krueppel-like factor 17, Zinc finger protein 393