KLF8
Domain
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF8, the motif is inactive.
Function
Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).
Post-translational modifications
Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.
Sequence Similarities
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
Alternative names
BKLF3, ZNF741, KLF8, Krueppel-like factor 8, Basic krueppel-like factor 3, Zinc finger protein 741