Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Prekallikrein deficiency
PKKD
An autosomal recessive condition characterized by a clotting defect due to prolongation of activated partial thromboplastin time. Affected individuals are clinically asymptomatic.
None
The disease is caused by variants affecting the gene represented in this entry.
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Found in plasma (at protein level).
KLK3, KLKB1, Plasma kallikrein, Fletcher factor, Kininogenin, Plasma prekallikrein, PKK
Proteins
Metabolism
71370Da
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