The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Prekallikrein deficiency
PKK deficiency
This disorder is a blood coagulation defect.
None
The disease is caused by variants affecting the gene represented in this entry.
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Proteins
71370Da
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