KRT1
GeneName
KRT1
Summary
KRT1, also known as cytokeratin, CK1, or CK-1, is a 66 kDa protein that plays a vital role in the structural integrity of the skin. It is primarily expressed in the epidermis, where it contributes to the formation of keratin filaments, essential for keratinization and the establishment of the skin barrier. KRT1 is localised in various cellular compartments, including the cytoplasm, nucleus, and cell membrane, and is involved in processes such as intermediate filament organisation and response to oxidative stress. Its functions extend to carbohydrate binding and protein heterodimerization, highlighting its versatility in cellular signalling and structural roles.
Importance
KRT1 is relevant to: - Skin health and integrity, as it is essential for the formation of the epidermal barrier and protection against environmental stressors - Inflammatory skin conditions, where its regulatory role in the inflammatory response may impact disease progression - Wound healing processes, given its involvement in keratinisation and extracellular matrix organisation - Research into skin-related disorders, including ichthyosis and other keratinisation disorders, where mutations in KRT1 can lead to clinical manifestations.
Top Products
For researchers investigating KRT1, we highly recommend the top-selling recombinant antibody, Anti-pan Cytokeratin antibody [C-11] (ab7753). This well-cited antibody has garnered 206 citations, reflecting its strong reputation in the field. It has been validated for use in immunohistochemistry (IHC), immunocytochemistry (ICC), and flow cytometry (FC), making it a versatile choice for various experimental needs. The recombinant nature of this antibody ensures batch-to-batch consistency, providing reliable results for your research on KRT1.
Abcam Product Citation Summary
The use of Abcam antibody ab106166 for detecting KRT1 in bovine endometrial cells highlights its application in reproductive biology research, particularly in understanding the role of keratins in the endometrium.
Abcam Product Citation Table
Function
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Involvement in disease
Epidermolytic hyperkeratosis 1
EHK1
A skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop. EHK1 inheritance is autosomal dominant or autosomal recessive.
None
The disease is caused by variants affecting the gene represented in this entry.
Ichthyosis hystrix, Curth-Macklin type
IHCM
A genodermatosis with severe verrucous hyperkeratosis. Affected individuals manifest congenital verrucous black scale on the scalp, neck, and limbs with truncal erythema, palmoplantar keratoderma and keratoses on the lips, ears, nipples and buttocks.
None
The disease is caused by variants affecting the gene represented in this entry.
Keratoderma, palmoplantar, non-epidermolytic
NEPPK
A dermatological disorder characterized by well-demarcated hyperkeratosis is present over the palms and soles. A red band is frequently present at the periphery of the keratosis. It is usually non-transgredient, with a sharp demarcation of the lesions at the wrists.
None
The disease is caused by variants affecting the gene represented in this entry.
Ichthyosis, annular epidermolytic, 2
AEI2
A form of annular epidermolytic ichthyosis, an autosomal dominant skin disorder characterized by polycyclic, migratory erythematous and scaly plaques. AEI2 patients manifest erythema and blistering of skin at birth that improves without scarring, as well as palmoplantar keratoderma.
None
The disease is caused by variants affecting the gene represented in this entry.
Keratoderma, palmoplantar, striate 3
SPPK3
A dermatological disorder characterized by thickening of the stratum corneum and epidermal layers on palms and soles. There is no involvement of non-palmoplantar skin, and both hair and nails are normal.
None
The disease is caused by variants affecting the gene represented in this entry.
Palmoplantar keratoderma, epidermolytic, 2
EPPK2
A form of epidermolytic palmoplantar keratoderma, a dermatological disorder characterized by diffuse thickening of the epidermis on the entire surface of palms and soles sharply bordered with erythematous margins. Some patients may present knuckle pads, thick pads of skin appearing over the proximal phalangeal joints. EPPK2 is an autosomal dominant form in which hyperkeratosis is restricted to palms and soles and is apparent from birth or childhood.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Undergoes deimination of some arginine residues (citrullination).
Sequence Similarities
Belongs to the intermediate filament family.
Tissue Specificity
The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.
Cellular localization
- Cell membrane
- Cytoplasm
Alternative names
KRTA, KRT1, 67 kDa cytokeratin, Cytokeratin-1, Hair alpha protein, Keratin-1, Type-II keratin Kb1, CK-1, K1
Database links
swissprot:P04264 swissprot:P13645 swissprot:P19012 swissprot:P02533 swissprot:P08779 omim:148080 swissprot:P13646 swissprot:P13647 omim:148066 omim:148040 omim:139350 swissprot:Q9H3D4 entrezGene:3868 entrezGene:8626 entrezGene:3866 entrezGene:3861 entrezGene:3860 entrezGene:3858 entrezGene:3852 entrezGene:3848 swissprot:Q7Z794 swissprot:Q01546 entrezGene:51350 entrezGene:374454