KRT10

Function

Plays a role in the establishment of the epidermal barrier on plantar skin.

(Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.

(Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.

Involvement in disease

Epidermolytic hyperkeratosis

EHK

An autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.

None

The disease is caused by variants affecting the gene represented in this entry.

Ichthyosis annular epidermolytic

AEI

A skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.

None

The disease is caused by variants affecting the gene represented in this entry.

Erythroderma, ichthyosiform, congenital reticular

CRIE

A rare skin condition characterized by slowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. The condition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearing in late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis, and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloid deposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of fine filaments in the upper epidermis.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the intermediate filament family.

Tissue specificity

Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines (PubMed:19627498).

Cellular localization

• Secreted
• Extracellular space
• Cell surface
• Localized on the surface of desquamated nasal epithelial cells (PubMed:12427098). Localized on the surface of lung cell lines (PubMed:19627498).

Alternative names

• Cytokeratin-10
• Keratin-10
• CK-10
• K10
• KPP
• KRT10

Database links

• entrezGene:3858
• entrezGene:3860
• entrezGene:51350
• entrezGene:374454
• omim:148065
• omim:148080
• swissprot:P13645
• swissprot:Q01546
• swissprot:Q7Z794
• swissprot:P13646

Target type

Proteins

Molecular weight

58827Da