KRT16
Function
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Involvement in disease
Pachyonychia congenita 1
PC1
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
None
The disease is caused by variants affecting the gene represented in this entry.
Keratoderma, palmoplantar, non-epidermolytic, focal 1
FNEPPK1
A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present.
None
The disease is caused by variants affecting the gene represented in this entry.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
Sequence Similarities
Belongs to the intermediate filament family.
Tissue Specificity
Expressed in the corneal epithelium (at protein level).
Alternative names
KRT16A, KRT16, Cytokeratin-16, Keratin-16, CK-16, K16