KRT19
GeneName
KRT19
Summary
KRT19, also known as K19, CK-19, or CK 19, is a 44 kDa intermediate filament protein primarily expressed in epithelial tissues. It is a component of the cytoskeleton and plays a crucial role in maintaining the structural integrity of cells. KRT19 is involved in various biological processes, including epithelial cell differentiation, cell differentiation in embryonic placenta development, and intermediate filament organisation. Additionally, it participates in the Notch signalling pathway and responds to estrogen, highlighting its role in cellular signalling and development.
Importance
KRT19 is relevant to: - Understanding epithelial cell biology and differentiation, which is essential for developmental biology and tissue engineering. - Cancer research, as it is often used as a marker for epithelial-derived tumours and can provide insights into tumour progression and metastasis. - Studies of placental development and function, particularly in the context of pregnancy and related complications. - Investigating the role of intermediate filaments in maintaining cellular architecture and their implications in various diseases.
Top Products
For researchers investigating KRT19, we highly recommend the top-selling recombinant antibody, Anti-Cytokeratin 19 antibody [EP1580Y] (ab52625). This antibody is well-cited, with 349 citations, reflecting its strong reputation in the field. It has been validated for use in a variety of applications, including immunohistochemistry (IHC), immunocytochemistry (ICC), western blotting (WB), and flow cytometry (FC). The recombinant nature of this antibody ensures batch-to-batch consistency, making it an excellent choice for reliable KRT19 detection in your experiments. The Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker ELISA Kit (ab52625) is an excellent option for researchers looking to accurately measure KRT19, supported by an impressive 349 citations.
Abcam Product Citation Summary
The data indicates that KRT19 is being extensively studied in various contexts related to stem cells and cancer, particularly in hepatic and pancreatic tissues. The use of multiple applications such as immunofluorescence, immunohistochemistry, and Western blotting highlights the importance of KRT19 as a marker in these biological processes.
Abcam Product Citation Table
Developmental stage
Present in hair follicles at all stages of development.
Domain
This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
Function
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Sequence Similarities
Belongs to the intermediate filament family.
Tissue Specificity
Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
Alternative names
Cytokeratin-19, Keratin-19, CK-19, K19, KRT19, ck19, ck 19