Krt5
Developmental stage
Expressed in basal layer cells of the stratified squamous epithelia at 15.5 dpc (PubMed:29518391). Expressed in the skin after birth (PubMed:29518391). Expressed in ameloblasts at the cervical and apical mid-regions of mandibular molars at birth, abundance at the apical mid-region significantly increases at P1, and is maintained throughout enamel development until P9 when ameloblasts start losing their integrity (PubMed:12657653). Expressed in ameloblasts at the incisal region of mandibular molars at P3 (PubMed:12657653). Expressed at the Tomes' processes of ameloblasts at the incisal region at P5 (PubMed:12657653). Expression at the incisal region decreased at P7 and P9 (PubMed:12657653). Weakly expressed in the spinous and granular layers of the tongue at P20 (PubMed:32758484).
Function
Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress (PubMed:11408584). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (PubMed:19267394).
Post-translational modifications
Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle (PubMed:29518391). Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis (PubMed:29518391). CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury (PubMed:29518391).
O-glycosylated.
Sequence Similarities
Belongs to the intermediate filament family.
Tissue Specificity
Expressed in the corneal epithelium (at protein level) (PubMed:11408584, PubMed:26758872). Expressed in the epidermis of the ear (at protein level) (PubMed:24751727). Expressed in the basal and spinous layers of the skin at birth (at protein level) (PubMed:11408584).
Cellular localization
- Cytoplasm
Alternative names
Krt2-5, Krt5, Cytokeratin-5, Keratin-5, Type-II keratin Kb5, CK-5, K5