KRT7
GeneName
KRT7
Summary
KRT7, also known as Scl or CK7, is a 51 kDa protein that is primarily expressed in epithelial tissues, particularly in the skin and various glandular tissues. It is a member of the keratin family and plays a crucial role in the structural integrity of the epidermis. KRT7 is localised to the cytoplasm and is a key component of intermediate filaments, contributing to the organisation of the cytoskeleton. Its functions are particularly important in processes such as keratinisation and the maintenance of cellular architecture.
Importance
KRT7 is relevant to: - Understanding skin diseases and conditions related to keratinocyte function and differentiation - Investigating epithelial cancers, as its expression patterns can serve as diagnostic markers - Studying tissue repair and regeneration processes, particularly in response to injury - Exploring the role of keratins in cellular responses to stress and environmental factors
Top Products
For researchers investigating KRT7, we highly recommend the Anti-Cytokeratin 7 antibody [EPR17078] (ab181598). This top-selling recombinant monoclonal antibody is well-cited, with 163 citations, reflecting its strong reputation in the field. It has been validated in knockout models and is suitable for a variety of applications, including immunohistochemistry (IHC), immunocytochemistry (ICC), western blotting (WB), and flow cytometry (FC). This versatility makes it an excellent choice for those seeking reliable detection of KRT7 in their studies.
Abcam Product Citation Summary
The data indicates that KRT7 is being studied in various contexts, particularly in relation to cancer and tissue inflammation. The use of KRT7 antibodies in both western blotting and immunohistochemistry across different species highlights its relevance in understanding tumor biology and associated pathologies.
Abcam Product Citation Table
Function
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Post-translational modifications
Arg-20 is dimethylated, probably to asymmetric dimethylarginine.
Sequence Similarities
Belongs to the intermediate filament family.
Tissue Specificity
Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.
Cellular localization
- Cytoplasm
Alternative names
SCL, KRT7, Cytokeratin-7, Keratin-7, Sarcolectin, Type-II keratin Kb7, CK-7, K7
Database links
swissprot:P08729 omim:148059 swissprot:Q04695 entrezGene:3872 entrezGene:3855