KRT8 phospho S73
Function
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Involvement in disease
Cirrhosis
CIRRH
A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
Sequence Similarities
Belongs to the intermediate filament family.
Tissue Specificity
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Cellular localization
- Cytoplasm
- Nucleus
- Nucleoplasm
- Nucleus matrix
Alternative names
CYK8, KRT8, Cytokeratin-8, Keratin-8, Type-II keratin Kb8, CK-8, K8