KRTAP2-4
Function
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
Sequence Similarities
Belongs to the KRTAP type 2 family.
Tissue Specificity
Expressed specifically in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.
Alternative names
KAP2.4, KRTAP2.4, KRTAP2-4, Keratin-associated protein 2-4, High sulfur keratin-associated protein 2.4, Keratin-associated protein 2.4