KYAT1
Function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19338303, PubMed:28097769). Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites (PubMed:7883047). Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047).
Pathway
Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.
Sequence Similarities
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Cellular localization
- Cytoplasm
- Cytosol
Alternative names
CCBL1, KYAT1, Kynurenine--oxoglutarate transaminase 1, Cysteine-S-conjugate beta-lyase, Glutamine transaminase K, Glutamine--phenylpyruvate transaminase, Kynurenine aminotransferase 1, Kynurenine aminotransferase I, Kynurenine--oxoglutarate transaminase I, GTK, KATI