L3
Function
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
Sequence Similarities
Belongs to the adenoviridae hexon protein family.
Cellular localization
- Virion
- Host nucleus
- Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers.
Alternative names
Hexon protein, CP-H, Protein II, L3