LACTB2
Function
Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.
Sequence Similarities
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Cellular localization
- Mitochondrion matrix
Alternative names
CGI-83, LACTB2, Endoribonuclease LACTB2, Beta-lactamase-like protein 2