Lama1

Domain

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.

Domains VI, IV and G are globular.

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Post-translational modifications

Tyrosine phosphorylated by PKDCC/VLK.

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix
• Basement membrane
• Major component.

Alternative names

Lama, Lama-1, Lama1, Laminin subunit alpha-1, Laminin A chain, Laminin-1 subunit alpha, Laminin-3 subunit alpha, S-laminin subunit alpha, S-LAM alpha

Database links

swissprot:P19137 entrezGene:16772 swissprot:Q8R0Y0 swissprot:P02468 entrezGene:16773 entrezGene:16779 entrezGene:16782 entrezGene:226519