Laminin 2 alpha

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.

Domains VI, IV and G are globular.

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Defects in Lama2 are a cause of murine muscular dystrophy (dy2J).

• Secreted
• Extracellular space
• Extracellular matrix
• Basement membrane
• Major component.

Laminin subunit alpha-2, Laminin M chain, Laminin-12 subunit alpha, Laminin-2 subunit alpha, Laminin-4 subunit alpha, Merosin heavy chain, Lama2

• entrezGene:16773
• swissprot:Q60675

Proteins

Neuroscience

343815Da