Lamc3
Domain
The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain IV is globular.
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Tissue Specificity
Strongly expressed in capillaries and arterioles of kidney as well as in interstitial Leydig cells of testis.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Basement membrane
Alternative names
Laminin subunit gamma-3, Laminin-12 subunit gamma, Laminin-14 subunit gamma, Laminin-15 subunit gamma, Lamc3