Lamp1

Function

Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:15121881). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Also plays an important role in NK-cells cytotoxicity (PubMed:23847195). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (By similarity). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (By similarity). Also implicated in tumor cell metastasis (PubMed:2676155).

Post-translational modifications

O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans.

Sequence Similarities

Belongs to the LAMP family.

Cellular localization

• Lysosome membrane
• Single-pass type I membrane protein
• Endosome membrane
• Single-pass type I membrane protein
• Late endosome membrane
• Single-pass type I membrane protein
• Cell membrane
• Single-pass type I membrane protein
• Cytolytic granule membrane
• Single-pass type I membrane protein
• This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (By similarity).

Alternative names

CD107a, Lamp-1, Lamp1, Lysosome-associated membrane glycoprotein 1, LAMP-1, Lysosome-associated membrane protein 1, 120 kDa lysosomal membrane glycoprotein, CD107 antigen-like family member A, LGP-120, Lysosomal membrane glycoprotein A, P2B, LGP-A

Database links

swissprot:P11438 entrezGene:16783

Other research areas

• Immuno-oncology
• Immunology & Infectious Disease
• Oncology