LAMP1

Function

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

(Microbial infection) Acts as a receptor for Lassa virus protein.

Post-translational modifications

O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.

Sequence similarities

Belongs to the LAMP family.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Endosome membrane
• Single-pass type I membrane protein
• Lysosome membrane
• Single-pass type I membrane protein
• Late endosome membrane
• Single-pass type I membrane protein
• Cytolytic granule membrane
• Single-pass type I membrane protein
• This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980).

Alternative names

• Lysosome-associated membrane glycoprotein 1
• LAMP-1
• Lysosome-associated membrane protein 1
• CD107 antigen-like family member A
• LAMP1

Database links

• entrezGene:3916
• omim:153330
• swissprot:P11279

Target type

Proteins

Primary research area

Neuroscience

Other research areas

• Immuno-oncology
• Immunology & Infectious Disease
• Oncology

Molecular weight

44882Da