LAMTOR3

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Sequence similarities

Belongs to the LAMTOR3 family.

Cellular localization

• Late endosome membrane
• Peripheral membrane protein
• Cytoplasmic side

Alternative names

• Ragulator complex protein LAMTOR3
• Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
• MEK-binding partner 1
• Mitogen-activated protein kinase kinase 1-interacting protein 1
• Mitogen-activated protein kinase scaffold protein 1
• Mp1
• PRO2783
• MAPKSP1
• MAP2K1IP1
• LAMTOR3

Database links

• entrezGene:8649
• omim:603296
• swissprot:Q9UHA4

Target type

Proteins

Molecular weight

13623Da