LANCL1
Function
Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316).
Sequence Similarities
Belongs to the LanC-like protein family.
Tissue Specificity
Detected in erythrocytes, brain, kidney, testis, ovary, heart, lung, placenta and spleen (at protein level). Ubiquitous. Strongly expressed in brain, spinal cord, pituitary gland, kidney, heart, skeletal muscle, pancreas, ovary and testis.
Cellular localization
- Cytoplasm
- Cell membrane
- Peripheral membrane protein
Alternative names
GPR69A, LANCL1, Glutathione S-transferase LANCL1, 40 kDa erythrocyte membrane protein, LanC-like protein 1, p40