LANCL2
Function
Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
Post-translational modifications
Myristoylated. Essential for membrane association.
Sequence Similarities
Belongs to the LanC-like protein family.
Tissue Specificity
Expressed in brain and testis.
Cellular localization
- Nucleus
- Cytoplasm
- Cell membrane
- Localizes to the juxta-nuclear vesicles (PubMed:16979580). Associates with the cortical actin cytoskeleton (PubMed:16979580). Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580).
Alternative names
GPR69B, TASP, LANCL2, LanC-like protein 2, Testis-specific adriamycin sensitivity protein