LANCL2

Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.

Myristoylated. Essential for membrane association.

Belongs to the LanC-like protein family.

Expressed in brain and testis.

• Nucleus
• Cytoplasm
• Cell membrane
• Localizes to the juxta-nuclear vesicles (PubMed:16979580). Associates with the cortical actin cytoskeleton (PubMed:16979580). Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580).

GPR69B, TASP, LANCL2, LanC-like protein 2, Testis-specific adriamycin sensitivity protein

• entrezGene:55915
• swissprot:Q9NS86

Proteins

Immunology & Infectious Disease

50854Da