LAPTM4B
Function
Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).
Post-translational modifications
Undergoes proteolytic cleavage following delivery to the lysosomes.
Ubiquitinated by NEDD4.
Sequence Similarities
Belongs to the LAPTM4/LAPTM5 transporter family.
Cellular localization
- Endomembrane system
- Multi-pass membrane protein
- Late endosome membrane
- Cell membrane
- Cell projection
- Lysosome membrane
- Endosome membrane
- Endosome
- Multivesicular body membrane
- Endosome
- Multivesicular body lumen
Alternative names
PSEC0001, LAPTM4B, Lysosomal-associated transmembrane protein 4B, Lysosome-associated transmembrane protein 4-beta