LARP6
Domain
The RRM domain mediates the association with collagen mRNAs stem-loops.
Function
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.
Tissue Specificity
Expressed in numerous tissues.
Cellular localization
- Cytoplasm
- Nucleus
- Shuttles between the nucleus and the cytoplasm.
Alternative names
La-related protein 6, Acheron, La ribonucleoprotein domain family member 6, Achn, LARP6