LBP

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:24120359, PubMed:7517398). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24120359, PubMed:7517398).

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Detected in blood serum (at protein level).

• Secreted
• Cytoplasmic granule membrane
• Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.

Lipopolysaccharide-binding protein, LBP

• swissprot:P18428

Proteins

Metabolism

53384Da