LCOR

Function

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.

Tissue Specificity

Ubiquitous.

Cellular localization

• Nucleus

Alternative names

C10orf12, KIAA1795, MLR2, LCOR, Ligand-dependent corepressor, LCoR, Mblk1-related protein 2

Database links

swissprot:Q96JN0 entrezGene:84458 entrezGene:26148 swissprot:Q8N655 omim:607698