LDB1

Domain

The dimerization domain is located in the N-terminus.

Function

Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state.

Post-translational modifications

Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome.

Sequence Similarities

Belongs to the LDB family.

Tissue Specificity

Expressed in a wide range of adult tissues including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.

Cellular localization

• Nucleus
• Colocalizes with SLK at leading edges.

Alternative names

CLIM2, LDB1, LIM domain-binding protein 1, LDB-1, Carboxyl-terminal LIM domain-binding protein 2, LIM domain-binding factor CLIM2, Nuclear LIM interactor, CLIM-2, hLdb1

Database links

swissprot:Q86U70 omim:603451 genbank:26002 genbank:NM_003893 entrezGene:8861