LDHA

Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).

Glycogen storage disease 11

GSD11

A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.

None

The disease is caused by variants affecting the gene represented in this entry.

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

ISGylated.

Belongs to the LDH/MDH superfamily. LDH family.

Predominantly expressed in anaerobic tissues such as skeletal muscle and liver.

• Cytoplasm

PIG19, LDHA, L-lactate dehydrogenase A chain, LDH-A, Cell proliferation-inducing gene 19 protein, LDH muscle subunit, Renal carcinoma antigen NY-REN-59, LDH-M

• entrezGene:3939
• entrezGene:3945
• omim:150000
• omim:150100
• swissprot:P00338
• swissprot:P07195
• swissprot:P07864

Proteins

Metabolism

• Immunology & Infectious Disease
• Oncology

36689Da