L-lactate dehydrogenase B

Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).

Lactate dehydrogenase B deficiency

LDHBD

A condition with no deleterious effects on health. LDHBD is of interest to laboratory medicine mainly because it can cause misdiagnosis in those disorders in which elevation of serum LDH is expected.

None

The disease is caused by variants affecting the gene represented in this entry.

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Belongs to the LDH/MDH superfamily. LDH family.

Predominantly expressed in aerobic tissues such as cardiac muscle.

• Cytoplasm
• Mitochondrion inner membrane
• Peripheral membrane protein

L-lactate dehydrogenase B chain, LDH-B, LDH heart subunit, Renal carcinoma antigen NY-REN-46, LDH-H, LDHB

• entrezGene:3939
• entrezGene:3945
• omim:150000
• omim:150100
• swissprot:P07195
• swissprot:P00338
• swissprot:P07864

Proteins

Metabolism

• Immunology & Infectious Disease
• Oncology

36638Da