LDLRAD3
Function
May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353).
(Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus.
Sequence Similarities
Belongs to the LDLR family.
Tissue Specificity
Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
LRAD3, LDLRAD3, Low-density lipoprotein receptor class A domain-containing protein 3, LDLR class A domain-containing protein 3