Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.
Belongs to the TGF-beta family.
LEFTB, LEFTYB, UNQ278/PRO317, LEFTY1, Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B
Proteins
Developmental Biology
40880Da
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