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LEFTY1

Function

Required for left-right axis determination as a regulator of LEFTY2 and NODAL.

Post-translational modifications

The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Sequence Similarities

Belongs to the TGF-beta family.

Cellular localization

Alternative names

LEFTB, LEFTYB, UNQ278/PRO317, LEFTY1, Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B

swissprot:O75610 omim:603037 entrezGene:10637