LGALS1

Function

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69 (PubMed:24752896).

Tissue specificity

Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix
• Cytoplasm
• Secreted
• Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.

Alternative names

• Galectin-1
• Gal-1
• 14 kDa laminin-binding protein
• 14 kDa lectin
• Beta-galactoside-binding lectin L-14-I
• Galaptin
• HBL
• HPL
• Lactose-binding lectin 1
• Lectin galactoside-binding soluble 1
• Putative MAPK-activating protein PM12
• S-Lac lectin 1
• HLBP14
• LGALS1

Database links

• entrezGene:3956
• omim:150570
• swissprot:P09382

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

14716Da