LGMN
Domain
In the zymogen form, the uncleaved propeptide blocks access to the active site.
Function
Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:23776206). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:23776206). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (PubMed:9872320). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity).
Post-translational modifications
Activated by autocatalytic processing at pH 4.
Sequence Similarities
Belongs to the peptidase C13 family.
Tissue Specificity
Ubiquitous. Particularly abundant in kidney, heart and placenta.
Cellular localization
- Lysosome
Alternative names
PRSC1, LGMN, Legumain, Asparaginyl endopeptidase, AEP